agripa

Laboratorio de Interacción virus-célula

Departamento de Biotecnología del INIA
Descripción

Nuestro laboratorio estudia las interacciones patógeno-huésped y la inmunidad innata para identificar componentes celulares cruciales en la infección. Nuestro modelo de trabajo es el virus de la Peste porcina africana (VPPA). El VPPA causa una enfermedad aguda mortal en el cerdo doméstico pero en cambio solo produce infecciones inaparentes persistentes en los cerdos salvajes africanos.  Nuestro objetivo es conocer mas la infección para identificar dianas para nuevas estrategias vacunales. Además, la identificación de moléculas clave para que los virus puedan llevar a cabo su infección y que se pueden eliminar mediante “gene editing” ha permitido el desarrollo de animales genéticamente resistentes, al virus del PRRS, por ejemplo (Whitworth K.M. et al, 2015)

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Últimas publicaciones

69 Alonso, C., Borca, M., Dixon, L., Revilla, Y., Rodriguez, F., Escribano, J.M., and ICTV Report Consortium. 2018. ICTV Virus Taxonomy Profile: Asfarviridae Journal of General Virology J GEN VIROL, ISSN 0022-1317 doi 10.1099/jgv.0.001049 www.ictv.global/report/asfarviridae

68 Alonso C. et al., African Swine Fever (ASF): Gap Analysis Workshop Report. 2018. Agricultural Research Service, Washington, D.C. USA. https://www.ars.usda.gov/GARA/reports.htm https://go.usa.gov/xPfWr

67 Dalmau-Mena I., P. del Pino, B. Pelaz, M.A. Cuesta-Geijo, I. Galindo, M. Moros, J.M. de la Fuente and C. Alonso. Nanoparticles engineered to bind cellular motors for high eficient delivery. Journal of Nanobiotechnology 16: 33, 2018. CLAVE: A doi: 10.1186/s12951-018-0354-1

66 Barrado-Gil L., I. Galindo, S. Viedma and C. Alonso. 2017. The ubiquitin-proteasome system is required for African swine fever replication. PLoS ONE  12: e0189741. doi: 10.1371/journal.pone.0189741

65 Hakobyan A., I. Galindo, A. Nañez, E. Arabyan, Z. Karalyan, A. A. Chistov, P.P. Streshnev, V.A. Korshun, C. Alonso and H. Zakaryan. 2017. Rigid amphipathic fusion inhibitors demonstrate antiviral activity against African swine fever virus. Journal General Virology  99:148-156 doi 10.1099/jgv.0.000991

64 Dixon LK, PJ Sánchez-Cordón, I. Galindo and C. Alonso. 2017. Investigations of Pro- and Anti-apoptotic factors affecting African swine fever virus replication and pathogenesis. Viruses 9, 241. doi: 10.3390/v9090241

63 Cuesta-Geijo M.A., L. Barrado-Gil, I. Galindo, R. Muñoz-Moreno and C. Alonso. 2017. Redistribution of Endosomal membranes to the African swine fever virus replication site. Viruses 9, 133. doi: 10.3390/v9060133
Galindo I. and C. Alonso. 2017. African Swine Fever Virus: A Review. Viruses  9, 103. doi: 10.3390/v9050103

62 González-Aramundiz, J.V., E. Presas, I. Dalmau-Mena, S. Martínez-Pulgarín, C. Alonso, J.M. Escribano, M.J. Alonso. 2016. Rational Design of Protamine Nanocapsules as Antigen Delivery Carriers. Journal of Controlled Release 245: 62-69. doi: 10.1016/j.jconrel.2016.11.012

61 Borca M.V., V. O’Donnell, L.G. Holinka,  D.K. Rai, B. Stanford, M. Alfano, J. Carlson, P.A. Azzinaro, C. Alonso, D.P. Gladue. 2016. Identification of a BAT3 as an essential host factor for African Swine Fever Virus protein EP152R. Virus Research Sept;223:181-189. DOI: 10.1016/j.virusres.2016.07.013

60 Muñoz-Moreno R., M.A. Cuesta-Geijo, C. Martínez-Romero, L. Barrado-Gil, I. Galindo, A. García-Sastre and C. Alonso. 2016. Antiviral role of Interferon-induced Transmembrane proteins in African swine fever virus infection PLoS ONE11(4): e0154366. CLAVE: A. DOI:10.1371/journal.pone.0154366 

59 Klionsky D.J.,...C. Alonso…et al. 2016. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy, 2nd Edition. Autophagy 12 (1), 1-222, 2016. IF 11,753. DOI: 10.1080/15548627.2015. 1100356

58 Cuesta-Geijo M.A., M. Chiappi, I. Galindo, L. Barrado-Gil,  R. Muñoz-Moreno, José L. Carrascosa and C. Alonso. 2016. Cholesterol flux is required for endosomal progression of African swine fever virus. Journal of Virology 90 (3): 1534-43. doi: 10.1128/JVI.02694-15. CLAVE:A IF: 4.439  PMID: 26608317

57 Metz, G.E., I. Galindo, M.M. Abeyá, M.G. Echeverría and C. Alonso. 2016. Intrinsic, Extrinsic and Endoplasmic Reticulum stress-induced apoptosis in RK13 cells infected with Equine Arteritis Virus. Virus Research 213: 219-223. DOI: 10.1016/j.virusres.2015.12.010

56 Muñoz-Moreno R., I. Galindo, M.A. Cuesta-Geijo, L. Barrado-Gil and C. Alonso. 2015. Host cell targets for African swine fever virus. Special issue Cell Response to Viral Infection. Virus Research, 209: 118-127. doi:10.1016/j.virusres.2015.05.026 

55 Muñoz-Moreno R., L. Barrado-Gil, I. Galindo and C. Alonso. 2015. Analysis of HDAC6 and BAG3-aggresome pathways in African swine fever viral factory formation. Viruses 7, 1823-1831 doi: 10.3390/v7041823 

54 Galindo I., M.A. Cuesta-Geijo, K. Hlavova, R. Muñoz-Moreno, Lucía Barrado-Gil, Javier Dominguez and C. Alonso. 2015. African swine fever virus infects macrophages, the natural host cells, via clathrin- and cholesterol-dependent endocytosis. Virus Research, 200: 45-55. doi: 10.1016/j.virusres.2015.01.022. 

53 C. Alonso. African swine fever conquers new territories. Virus Research 2013 173: 1-2. CLAVE:A IF: 2.941PMID: 23376880

52 C. Alonso, I. Galindo, M.A. Cuesta-Geijo, M. Cabezas, B. Hernáez, R. Muñoz-Moreno. African Swine Fever Virus-Cell Interactions: From Virus Entry to Cell Survival. Virus Research 2013 173: 42-57. PMID:2326216

51 Hernaez B., M. Cabezas, R. Muñoz-Moreno, I. Galindo, M.A.Cuesta-Geijo and C. Alonso. A179L, a new viral Bcl2 homolog targeting Beclin 1 autophagy related protein. Current Molecular Medicine 2013,13(2): 305-316. IF: 5.10 PMID: 23228131

50 Escribano J.M., I. Galindo, C. Alonso. Antibody-mediated neutralization of African swine fever virus. Myths and facts. Virus Research 2013 173: 101-109. 

49 Cuesta-Geijo M.A., I. Galindo, B. Hernáez, J.I. Quetglás, I. Dalmau-Mena and C. Alonso. Endosomal maturation, Rab7 GTPase and Phosphoinositides in African Swine Fever Virus entry. PLoSONE 2012, 7: e48853. IF: 4.4 PMID:23133661

48 Galindo I., B. Hernáez, M.A. Cuesta-Geijo, I. Dalmau-Mena and C. Alonso. The ATF6 branch of Unfolded Protein Response and Apoptosis are activated to promote African Swine Fever virus infection. Cell Death and Disease 2012 Jul 5;3:e341. CLAVE:A IF: 6.044 (35/184 Cell Biology)PMID: 22764100

47 Moros M., B. Hernáez, E. Garet, J. T. Dias, B. Sáez, V. Grazu, A. González- Fernández, C. Alonso, J.M. De La Fuente.MonosaccharidesVersus PEG-Functionalized NPs: Influence in the Cellular Uptake. ACS Nano 2012. 6(2):1565-77. CLAVE:A IF: 9.865PMID: 22214244

46 Quetglas J.I., Hernaez B., I. Galindo, R. Muñoz-Moreno, M.A.Cuesta-Geijo and C. Alonso. Small Rho GTPases and cholesterol biosynthetic pathway intermediates in African swine fever virus infection. Journal of Virology2012 Feb;86(3):1758-67 CLAVE:A IF: 5.2PMID: 22114329

45 Galindo I., B. Hernáez, J. Berná, J. Fenoll, J.L. Cenis, J.M. Escribano and C. Alonso. 2011. Comparative inhibitory activity of stilbenes resveratrol and oxyresveratrol on African swine fever virus replication Antiviral Research 91: 57-63. DOI: 10.1016/j.antiviral.2011.04.013
                             
44 Hernáez B., T. Tarragó, E. Giralt, J. M. Escribano, and C. Alonso. 2010. Small Peptide Inhibitors Disrupt a High-Affinity Interaction between Cytoplasmic Dynein and a Viral Cargo Protein Journal of Virology 84 (20), 10792–10801, 2010. DOI: 10.1128/JVI.01168-10
 
43 Gil F., M. Perez-Filgueira, M. G. Barderas, C. Pastor-Vargas, C. Alonso, F. Vivanco and J. M. Escribano. 2010. Targeting antigens to an invariant epitope of the MHC Class II DR molecule potentiates the immune response to subunit vaccines.Virus Research 155: 55-60. DOI: 10.10 16/j.virusres.2010.08.022
 
42 Hernaez, B. and C. Alonso. 2010. Dynamin- and clathrin-dependent endocytosis in African swine fever virus entry. Journal of Virology 84(4):2100-9, 2010. DOI: 10.1128/JVI.01557-09
 
41 Hernáez B., J M. Escribano and C Alonso. 2008. The African swine fever virus protein p30 interacts with the heterogeneous ribonucleoprotein K (hnRNP-K) during infection FEBS Letters 582, 3275–3280, 2008. DOI: 10.1016/j.febslet.2008.08.031
 
40 Galindo I., B. Hernáez, G. Díaz-Gil, J.M. Escribano and C. Alonso. 2008. A179L, a viral Bcl-2 homologue, targets the core Bcl-2 apoptotic machinery and its upstream BH3 activators with selective binding restrictions for Bid and Noxa. Virology Vol 375(5): 561-572 DOI: 10.1016/j.virol.2008.01.050
 
39 Carpintero R., C. Alonso, M. Piñeiro, M. Iturralde, M. Andrés, F. Madec, M. A. Álava, A. Piñeiro, F. Lampreave. 2007. Pig-Major Acute-Phase Protein and apolipoprotein A-I response correlated with the severity of experimentally induced African Swine Fever and Aujeszky´s disease Veterinary Research 38: 741–753. DOI: 10.1051/vetres:2007030
 
38 Rivera J., C Abrahams, B Hernaez, A Alcázar, L Dixon, J M. Escribano and C Alonso. 2007. The MyD116-African Swine Fever viral homologue interacts with the catalytic subunit of protein phosphatase-1 and activates its phosphatase activity. Journal of Virology 81 (6): 2923- 2929. DOI: 10.1128/JVI.02077-06
 
37 Alfonso P., J.I. Quetglás, J.M. Escribano and C. Alonso. 2007. Protein pE120R of African swine fever virus is post-translationally acetylated as revealed by post-source decay MALDI mass spectrometry. Virus Genes 35 (1): 81- 85. DOI: 10.1007/s11262-006-0015-6

36 Pérez-Filgueira D. M., F. González-Camacho, C. Gallardo, P. Resino, E. Blanco, E. Gómez- Casado, C. Alonso and J. M. Escribano. 2006. Optimization and validation of recombinant serological tests for African swine fever diagnosis based on the p30 protein produced in Trichoplusia ni larvae Journal of Clinical Microbiology 44 (9): 3114–3121, 2006. DOI: 10.1128/JCM.00406-06 Impacto: 3.445 Citas 49

35 Hernaez, B., J. M. Escribano, C. Alonso. 2006. Visualization of the African swine fever virus infection in living cells, by incorporation into the virus particle of green fluorescent protein and p54 membrane protein chimera. Virology 350: 1-14. DOI: 10.1016/j.virol.2006.01.021 Cuartil: Q1 Impacto: 3.612 Citas 25

34 Hernáez, B.; G. Díaz- Gil, M. García-Gallo, J.I. Quetglas, I. Rodríguez-Crespo, L. Dixon, J.M. Escribano and C. Alonso. 2004. The African swine fever virus dynein-binding protein p54 induces infected cell apoptosis. FEBS Letters 569: 224-228. DOI: 10.1016/j.febslet.2004.06.001 Cuartil: Q2 Impacto: 3.912 Citas 16

33 Alfonso P., J. Rivera, B. Hernáez, C. Alonso and J. M. Escribano. 2004. Identification of cellular proteins modified in response to African swine fever virus infection by proteomics. Proteomics 7 (4), 2037- 2046. DOI: 10.1002/pmic.200300742 Cuartil: Q1 Bioquímica Impacto: 5.735 Citas 47

32 Tejera N., D Gómez-Garre, A. Lázaro, J. Gallego-Delgado, C Alonso, J Blanco, A Ortiz, J Egido.2004. Persistent proteinuria upregulates angiotensinII type2 receptor and induces apoptosis in proximal tubular cells. American Journal of Pathology 164: 1817- 1826. DOI: 10.1016/S0002-9440(10)63740-6 Cuartil: Q1 Patología Impacto: 5.9 Citas 45

31 Soto K., D. Gómez- Garre, R. Largo, J. Gallego- Delgado, N. Tejera, M.P. Catalán, A. Ortiz, J.J. Plaza, C. Alonso and J. Egido. 2004. Tight blood pressure control decreases apoptosis during renal damage. Kidney International 65(3): 811-82. DOI: 10.1111/j.1523-1755.2004.00455.x Cuartil: Q1 Impacto: 4.7 Citas 13

30 Martínez Moreno M., I Navarro- Lérida, F. Roncal, J.P. Albar, C. Alonso, F. Gavilanes and I. Rodríguez- Crespo. 2003. Recognition of novel viral sequences that associate to the dynein light chain LC8 identified through a Pepscan technique. FEBS Letters 544: 262-267. DOI: 10.1016/S0014-5793(03)00516-7 Cuartil: Q2 Impacto: 3.912 Citas 49

29 C. Alonso, J. Miskin, B. Hernáez, P. Fernandez-Zapatero, L. Soto, C. Cantó, I. Rodríguez-Crespo, L. Dixon, J.M. Escribano. 2001.The African swine fever virus protein p54 interacts with the microtubule motor complex through direct binding to light chain dynein. Journal of Virology 75 (20), 9819 -9827. DOI: 10.1128/JVI.75.20.9819-9827.2001 Cuartil: Q1 Impacto: 5.332 Citas 103

28 Barderas M.G., F. Rodríguez, P. Gómez-Puertas, M. Avilés, F. Beitia, C. Alonso, J.M. Escribano. 2001. Antigenic and immunogenic properties of a chimera of two immunodominant African swine fever virus proteins. Archives of Virology 146: 1-11. DOI: 10.1007/s007050170056

27. Barderas M.G., A. Wigdorovitz, F. Merelo, F. Beitia, Alonso, M.V. Borca, J.M. Escribano. Serodiagnosis of African swine fever using the recombinant protein p30 expressed in insect larvae. Journal of Virological Methods 89, 129-136, 2000. CLAVE: ADOI: 10.1016/S0166-0934(00)00209-3 Cuartil: Q2 Biotecnología Impacto: 2.1 Citas 27
 
26 Gomez del Moral M., E. Ortuño, P. Fernandez-Zapatero, F. Alonso, C. Alonso, A. Ezquerra and J. Dominguez. African swine fever virus infection induces tumor necrosis factor alpha production: Implications in pathogenesis. Journal of Virology 73: 2173-2180, 1999. PMCID: PMC104462 Cuartil: Q1 Impacto: 5.332 Citas 54
 
25 Ramiro-Ibáñez F., J.M. Martín-Alonso, P.García Palencia, F. Parra and C. Alonso. Macrophage tropism of Rabbit haemorrhagic disease virus and related organ pathology. Virus Research 60: 21-28, 1999. DOI: 10.1016/S0168-1702(98)00144-0 Cuartil: Q3 Virología. Impacto: 2,526

24 Martín Duque, P., C. Alonso, R. Sánchez-Prieto, M. E. Lleonart, C. Martínez, G. Gonzalez de Buitrago, A. Cano, M. Quintanilla and S. Ramón y Cajal. The adenovirus lacking the 19-kDa and 55-kDa E1B genes exerts a marked cytotoxic effect in human malignant cells. Cancer Gene Therapy 6: 554-563, 1999. DOI: 10.1038/sj.cgt.7700077 Cuartil: Q2 Biotecnología Impacto: 4.782 Citas 20
           
23 Guijarro C., L.M. Blanco-Colio, M. Ortego, C. Alonso, A. Ortiz, J.J. Plaza, C. Díaz, G. Hernandez and J. Egido. 3-hydroxy-3-methylglutaryl coenzyme A reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture. Circulation Research 83: 490-500, 1998. PMID: 9734471 Cuartil: Q1 Hematología Impacto: 9.854 Citas 358

22 Martín Duque, P., C. Alonso, R. Sánchez-Prieto and S. Ramón y Cajal. Antitumor effect of E1B-defective adenoviruses in human malignant cells. Adv Exp Med Biol 451: 87-89, 1998. CLAVE: A PMID: 10026855 Impacto: 4.782 Cuartil: Q2 Biotecnología
 
21 Martín Duque, P., C. Alonso, R. Sánchez-Prieto, M.E. Lleonart and S. Ramón y Cajal. Antitumoral effect of E1B defective adenoviruses in human malignant cells. Gene Therapy 5(2):286-287, 1998 DOI: 10.1038/sj.gt.3300585 Impacto: 4.538 Citas 10 Cuartil: Q1 Biotecnología                                          
 
20 Brun A., F. Rodriguez, J.M. Escribano, C. Alonso. Functionality and cell anchorage dependence in insect cells of the African swine fever virus gene A179L, a viral bcl-2 homolog. Journal of Virology 72: 10227-33, 1998. PMC110577 Impacto: 5.332 Citas 20 Cuartil: Q1
 
19 Alonso, C., E. Díaz, J.A. Boga and F. Parra. Programmed cell death in the pathogenesis of rabbit hemorrhagic disease. Archives of Virology 143: 1-12, 1998. DOI: 10.1007/s007050050289 Impacto: 1.967 Citas 52 Cuartil: N/D

18 Gomez-Puertas P., F. Rodriguez, J.M. Oviedo, A. Brun, C. Alonso and J.M. Escribano.The African swine fever virus proteins p54 and p30 are involved in two distinct steps of virus attachment and both contribute to the antibody-mediated protective immune response. Virology 243: 461- 471, 1998. CLAVE: A DOI: 10.1006/viro.1998.9068 Impacto: 3.612 Citas 59 Cuartil: Q1
 
17 Martin Duque P., C. Alonso, R. Sanchez-Prieto, M. Lleonart and S. Ramon y Cajal.
E1B gene defective adenoviruses as an antitumor treatment in human cancer.
European Journal of Cancer 1: 33, 1997. CLAVE: A Impacto: 1.2
 
16 Oviedo J.M., F. Rodriguez, P. Gómez-Puertas, A. Brun, N. Gómez, C.Alonso and J.M. Escribano. High level expression of the major antigenic African swine fever virus proteins p54 and p30 in baculovirus and their potential use as diagnostic reagents. Journal of Virological Methods 64: 27- 35, 1997. CLAVE: A DOI: 10.1016/S0166-0934(96)02140-4 Impacto: 2.1 Citas 17 Cuartil: Q2 Biotecnología         
 
15 Ramiro-Ibáñez F., A. Ortega, F. Ruiz-Gonzalvo, J.M. Escribano and C. Alonso.
Modulation of immune cell populations and activation markers in the pathogenesis of
African swine fever virus infection. Virus Research 47: 31- 40, 1997. CLAVE: A
DOI: 10.1016/S0168-1702(96)01403-7 Impacto: 3.4 Citas 24 Cuartil: Q2
           
14 Brun A., C. Rivas, M. Esteban, J.M. Escribano and C.Alonso. African swine fever virus gene A179L, a viral homologue of bcl-2, protects cells from programmed cell death. Virology 225, 227- 230, 1996. DOI: 10.1006/viro.1996.0592 Impacto: 3.612 Citas 65Cuartil: Q1

Ramiro-Ibañez F., A. Ortega, A. Brun, J.M. Escribano and C. Alonso. Apoptosis: a mechanism of cell killing and lymphoid organ impairment during acute African swine fever virus infection. Journal of General Virology 77, 2209- 2219, 1996. CLAVE: A
DOI: 10.1099/0022-1317-77-9-2209 Impacto: 3.7 Citas 49 Cuartil: Q1 Biotecnología
 
Gomez-Puertas P., F. Rodriguez, J.M. Oviedo, F. Ramiro-Ibáñez, F. Ruiz-Gonzalvo, C. Alonso and J.M. Escribano. Neutralizing antibodies to African swine fever virus inhibit through different proteins both virus attachment and internalization. Influence of passage history of the virus. Journal of Virology 70: 5689-5694, 1996. PMCID: PMC190536 Impacto: 6.194 Citas 54Cuartil: Q1
 
Torres J.M., C. Alonso, A. Ortega, S. Mittal, F. Graham and L. Enjuanes.
Tropism of human adenovirus Ad5 based vectors in swine and their use in protection against transmissible gastroenteritis coronavirus. Journal of Virology 70: 3770-80, 1996. PMID: 8648712 Impacto: 6.194 Citas 60 Cuartil: Q1
                       
Ramiro-Ibañez F., J.M. Escribano and C. Alonso. Application of a monoclonal antibody recognizing protein p30 to detect African swine fever virus infected cells in peripheral blood. Journal of Virological Methods 55: 339-345, 1995. DOI: 10.1016/0166-0934(95)00071-1
Impacto: 1.938 Citas 12
 
Gomez-Puertas P., F. Rodriguez, A. Ortega, J.M. Oviedo, C. Alonso and J.M. Escribano. Improvement of African swine fever virus neutralization assay using recombinant virus expressing chromogenic marker genes. Journal of Virological Methods 55: 271-279, 1995. DOI: 10.1016/0166-0934(95)00055-YImpacto: 1.938 Citas 13
 
Alcaraz C., F. Rodriguez, J.M. Oviedo, A. Eiras, M. De Diego, C. Alonso and J.M. Escribano. Highly specific confirmatory Western blot test for African swine fever virus antibody detection, using the recombinant virus protein p54. Journal of Virological Methods 52: 111-119, 1995. DOI: 10.1016/0166-0934(94)00150-F II: 1.938 Citas 15
 
Rodríguez F., C. Alcaraz, A. Eiras, R.J. Yañez, J.M. Rodríguez, C. Alonso, J.F. Rodríguez, J.M. Escribano. Characterization and molecular basis of heterogeneity of the African swine fever virus envelope protein p54. Journal of Virology 68: 7244 -7252, 1994. PMCID: PMC237164 Impacto: 6.254 Citas 41Cuartil: Q1
 
De Diego M., F. Rodriguez, C. Alcaraz, N. Gómez, C. Alonso, J.M. Escribano.
Characterization of the IgA and subclasses IgG response to neutralizing epitopes after infection of pregnant sows with the Transmissible gastroenteritis virus or the antigenically related porcine respiratory coronavirus. Journal of General Virology 75: 2585-2593, 1994. CLAVE: A DOI: 10.1099/0022-1317-75-10-2585 Ii: 3.478 Citas 8
Cuartil: Q2
Las siguientes publicaciones están firmadas por mi como C. Alonso-Martí:

Martín-Fernández J., A. Igual, A. Rueda, J.M. Sánchez-Vizcaíno, C. Alonso-Martí.
Glomerular pathology in surviving pigs experimentally infected with African swine fever virus. Histology and Histopathology 6: 115-121, 1991. CLAVE: A PMID: 1806048 Impacto: 2.502 Citas 7
                      
Alonso-Marti C., A. Moreno, A. Barat, J. Solera, H. Oliva. Coexistence of liver ground-glass inclusions originated by various causative agents. Histopathology 16: 304-307, 1990. CLAVE: A DOI: 10.1111/j.1365-2559.1990.tb01122.x Impacto: 3.855 Cuartil: Q1 Patología
           
Castrillo J.M., C. Rivas, C. Alonso-Marti, A. Varela, A. Gonzalo, M. Jiménez-Casado.
Malignant B cell immunoblastic lymphoma expresing CD 30 antigen in the terminal phase of a multiple myeloma. Applied Pathology 7: 375-381, 1989. CLAVE: A
PMID: 2561814 Impacto: 2.3 Citas 2 Cuartil: Q2 Patología
 
Gomiz León, J.J., Alonso-Marti, C., Piñango Angulo, L., García de la Peña, E., Alférez Villalobos, C. 1988. Retroperitoneal myxoid liposarcoma. Actas Urológicas Españolas 12 (2), 178-182.  PMID: 3414426

Patentes

PATENT RU2503686-C2 (WO/2009/053340) N.: European Patent EP2203468 (EP20080843012)  New antiviral composition comprises a peptide from African swine fever virus (ASFV) which prevents the binding of dynein light chain (DLC8), useful for treating infections attributable to a virus.Inventores: Covadonga Alonso, Jose M. Escribano, Bruno Hernáez.

PATENT WO/2012/110636 Carrier peptides for cell delivery. Inventors: Covadonga Alonso and Jose Escribano  No: US 2013/985.747-A1 Country: EEUU Submission: 29/10/2013 Date Granted 02/02/2017 Title: Carrier peptides for cell delivery. No: WO/2012/110636. Country: World Patent Date priority: 05/03/2011 Inventors: C Alonso and JM Escribano Owned by: INIA